Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma
Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma
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DOI：
10.1016/j.jneuroim.2015.07.003
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发表时间：
2015-09-15
影响因子：
3.3
通讯作者：
de Water, Judy Van
中科院分区：
文献类型：
--
作者：
Akintunde, Marjannie Eloi;Rose, Melissa;de Water, Judy Van
炎症和哮喘都在一些自闭症谱系障碍（ASD）儿童中报道。为了进一步评估这种联系，从患有ASD的幼儿和典型发育（TD）对照中分离的外周免疫细胞，以及在离体促分裂原刺激后评估的细胞因子IL-17、IL-13和IL-4的产生。值得注意的是，与对照组相比，ASD儿童在刺激后IL-17的产生显著更高。此外，与具有相同条件的对照组相比，患有哮喘的ASD儿童的IL-17增加。总之，与对照组相比，ASD儿童对T细胞刺激表现出不同的反应，IL-17的产生增加。(C)2015 Elsevier B. V.版权所有。
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. (C) 2015 Elsevier B.V. All rights reserved.