Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression?
Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression?
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DOI：
10.1007/s00535-009-0023-0
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发表时间：
2009-05-01
影响因子：
6.3
通讯作者：
Floreani, Annarosa
中科院分区：
文献类型：
--
作者：
Durazzo, Marilena;Niro, Grazia;Floreani, Annarosa
细胞因子可能作为炎症因子在肝脏疾病中发挥重要作用。有一些证据表明脂联素胆功能和肝脏疾病之间的联系。本研究的目的是阐明脂肪因子在自身免疫性肝炎1型中的作用。我们评估了42例自身免疫性肝炎患者的脂联素、肿瘤坏死因子-α、瘦素和瘦素的循环水平，并将其与42例年龄和性别匹配的健康受试者和31例非酒精性脂肪性肝炎（NASH）患者进行比较，评估其与细胞溶解标志物、与对照组相比，患者的脂联素和TNF-α值更高。经简单回归分析，患者显示出显著较高的稳态模型评估值，表明胰岛素抵抗增加，血清脂联素水平与γ-谷氨酰转肽酶和碱性磷酸酶值呈正相关。血清丙氨酸氨基转移酶和胆红素值升高与血清TNF-α水平呈正相关，丙氨酸氨基转移酶和血清丙氨酸氨基转移酶值升高与血清TNF-α水平呈正相关。脂联素浓度随疾病分期而显著升高。NASH患者的脂联素水平低于AIH患者和对照组，而血清HDL-C水平高于对照组，AIH患者的HOMA-IR值高于对照组，但其脂联素水平显著高于对照组。脂联素水平和胆汁淤积的血清学特征之间的显着相关性表明与胆道功能。我们的研究结果表明脂联素可能是AIH疾病进展的一个可能的标志物。
Cytokines may play an important role as inflammatory factors in liver diseases. There is some evidence suggesting a link between adiponectin-biliary function and liver disease. The aim of this study was to clarify the behavior of adipokines in autoimmune hepatitis type 1.We assessed the circulating levels of adiponectin, tumor necrosis factor-alpha, resistin and leptin in 42 patients with autoimmune hepatitis, comparing them with 42 healthy subjects who were matched for age and sex and with 31 patients with nonalcoholic steatohepatitis (NASH), evaluating the associations with markers of cytolysis, cholestasis, and histological severity.Adiponectin and TNF-alpha values were higher in patients compared to controls. The patients showed significantly higher Homeostasis Model Assessment values, suggesting an increased insulin resistance and serum levels of adiponectin positively correlated with gamma-glutamyltranspeptidase and alkaline phosphatase values after a simple regression analysis. Serum levels of resistin positively correlated with elevated aminotransferases and bilirubin values, and serum levels of TNF-alpha positively correlated with elevated alanine-aminotransferase and resistin values. The concentration of adiponectin increased significantly with staging of the disease. Patients with NASH showed lower levels of adiponectin and higher levels of resistin than AIH patients and controls.Patients with AIH showed significantly higher adiponectin concentrations than controls despite their higher HOMA-IR values. The significant correlation between adiponectin levels and serological features of cholestasis suggested an association with biliary function. Our results indicate that adiponectin may be a possible marker for disease progression in AIH.