Neurodegeneration: new clues on inclusions
Neurodegeneration: new clues on inclusions
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DOI：
10.1016/s1074-5521(00)00068-5
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发表时间：
2000-01-01
影响因子：
--
通讯作者：
Kosik, KS
中科院分区：
文献类型：
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作者：
Lansbury, PT;Kosik, KS
罕见的神经系统疾病额颞叶痴呆症和英国痴呆症与两种突变基因有关，它们的产物构成了定义这两种疾病病理的原纤维。最近的两项研究增加了越来越多的间接证据，即神经元内部（神经元缠结）或外部（淀粉样斑块）的蛋白质纤维化可能是致病的，并表明这些机制中的一种或两种都可能引发阿尔茨海默病。
The rare neurological disorders frontotemporal dementia and British dementia have been linked to two mutant genes whose products constitute the fibrils that define the two disease pathologies, Two recent studies add to the mounting circumstantial case that protein fibrillization, inside (neurofibrillary tangles) or outside (amyloid plaques) of the neuron, may be pathogenic and suggest that either or both of these mechanisms could initiate Alzheimer's disease.