Factor analysis of restricted and repetitive behaviors in autism using the Autism Diagnostic Interview-R
Factor analysis of restricted and repetitive behaviors in autism using the Autism Diagnostic Interview-R
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DOI：
10.1023/a:1025321707947
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发表时间：
2003-09-01
影响因子：
2.9
通讯作者：
Pericak-Vance, MA
中科院分区：
文献类型：
--
作者：
Cuccaro, ML;Shao, YJ;Pericak-Vance, MA
当前的研究考察了自闭症儿童的受限和重复行为（RRB）的因子结构。对207名自闭症患者应用了来自《自闭症诊断访谈修订版》（ADI - R）的12个条目的因子提取程序。确定了两个可解释的因子：因子1——重复的感觉运动行为和因子2——对变化的抗拒。适应功能水平指数与因子1之间存在显著的负相关。在有两个或更多自闭症兄弟姐妹的家庭子集（多发家庭）中，两个因子的组内相关性均不显著。当比较多发家庭和只有一名自闭症患者的家庭（单发家庭）时，两个因子的得分没有明显差异。自闭症中的受限和重复行为由两个不同的因子体现，这可能反映了自闭症中的两个不同群体。确定自闭症内的亚组将有助于减少临床异质性，并提高我们剖析这种复杂疾病的遗传病因的能力。
The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1-repetitive sensory motor actions and Factor 2-resistance to change. There was a significant negative correlation between an index of level of adaptive functioning and Factor 1. Intraclass correlations were not significant for either factor in a subset of families with two or more siblings with autism (multiplex). No differences in scores were apparent for either factor when multiplex families and families containing only one affected individual with autism (singleton) were compared. RRB in autism are represented by two distinct factors which may reflect two separate groups within autism. Defining subgroups within autism will allow for reduction of clinical heterogeneity and enhance our ability to dissect the genetic etiology of this complex disorder.