Association of diabetes, serum insulin, and C-peptide with gallbladder disease
Association of diabetes, serum insulin, and C-peptide with gallbladder disease
复制标题
DOI：
10.1002/hep.510310206
复制
发表时间：
2000-02-01
期刊：
影响因子：
13.5
通讯作者：
Everhart, JE
中科院分区：
文献类型：
--
作者：
Ruhl, CE;Everhart, JE
胆囊疾病和糖尿病之间的关系一直不一致。我们假设胰岛素抵抗而不是糖尿病状态可能是胆结石形成的主要因素。在第三次美国国家健康和营养调查中，共有5,653名成人参与者在空腹过夜后接受胆囊超声检查和静脉切开术，以测量血清胰岛素，C肽和葡萄糖。胆囊疾病被定义为超声记录的胆结石或胆囊切除术的证据。受试者的特征是空腹血糖正常（
An inconsistent association has been found between gallbladder disease and diabetes mellitus. We hypothesized that insulin resistance rather than diabetes status may be a primary factor involved in gallstone formation. A total of 5,653 adult participants in the third United States National Health and Nutrition Examination Survey without known diabetes underwent gallbladder ultrasonography and phlebotomy after an overnight fast for measurement of serum insulin, C-peptide, and glucose. Gallbladder disease was defined as ultrasound-documented gallstones or evidence of cholecystectomy. Subjects were characterized as having normal fasting glucose (