Helminth-derived immunomodulators: can understanding the worm produce the pill?
Helminth-derived immunomodulators: can understanding the worm produce the pill?
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DOI：
10.1038/nri2730
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发表时间：
2010-04-01
影响因子：
100.3
通讯作者：
Harnett, Margaret M.
中科院分区：
文献类型：
--
作者：
Harnett, William;Harnett, Margaret M.
蠕虫可以保护人类免受过敏和自身免疫性疾病的侵害，事实上，最近在小鼠模型中，确定的蠕虫衍生产品已被证明可以预防此类炎症性疾病的发展。在这里，我们提出蠕虫衍生产品不仅具有治疗潜力，而且还可以用作确定诱导抗炎反应的关键分子事件的独特工具，从而确定新的治疗靶点。
Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets.