The impact of α-lipoic acid, coenzyme Q10, and caloric restriction on life span and gene expression patterns in mice
The impact of α-lipoic acid, coenzyme Q10, and caloric restriction on life span and gene expression patterns in mice
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DOI：
10.1016/j.freeradbiomed.2004.01.015
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发表时间：
2004-04-15
影响因子：
7.4
通讯作者：
Prolla, TA
中科院分区：
文献类型：
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作者：
Lee, CK;Pugh, TD;Prolla, TA
我们评估了从中年（14个月）开始的三种饮食干预对小鼠衰老过程的延缓作用。这些是补充α -硫辛酸（LA）或辅酶Q(10) （CQ）和热量限制（CR，阳性对照）。与喂食相同卡路里的对照组小鼠相比，LA和CQ对寿命或肿瘤模式没有影响，而CR使最大寿命延长了13% (p
We evaluated the efficacy of three dietary interventions started at middle age (14 months) to retard the aging process in mice. These were supplemental alpha-lipoic acid (LA) or coenzyme Q(10) (CQ) and caloric restriction (CR, a positive control). LA and CQ had no impact on longevity or tumor patterns compared with control mice fed the same number of calories, whereas CR increased maximum life span by 13% (p