Allocrine modulation of feeding behavior by the sex peptide of Drosophila
Allocrine modulation of feeding behavior by the sex peptide of Drosophila
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DOI：
10.1016/j.cub.2006.02.064
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发表时间：
2006-04-04
期刊：
影响因子：
9.2
通讯作者：
Benzer, S
中科院分区：
文献类型：
--
作者：
Carvalho, GB;Kapahi, P;Benzer, S
交配会引发许多昆虫物种雌性行为的戏剧性重新编程。在果蝇中，这种交配后反应（PMR）包括产卵率增加和性感受性降低，并由雄性附腺的产物控制，附腺是一个类似于雄性精液中转移的80种小肽的家族[1-9]。在这里，我们表明，交配强烈刺激女性的食物摄入量。值得注意的是，如果雄性缺乏一种单一的、小的精液蛋白质，即性肽（SP），这种变化就会消失。异位表达的SP在处女女性模仿交配的摄食行为的影响，表明SP是控制这种行为范式的主要代理。我们的观察确定增强的摄食行为作为一个新的组成部分的果蝇PMR，并建议SP代表能量获取和生殖投资之间的分子联系。
Mating elicits a dramatic reprogramming of female behavior in numerous insect species. In Drosophila, this postmating response (PMR) comprises increased egg-laying rate and reduced sexual receptivity and is controlled by the products of the male accessory glands, a family of similar to 80 small peptides transferred in the male seminal fluid [1-9]. Here, we show that copulation strongly stimulates female food intake. Remarkably, this change is abolished if the males lack a single, small, seminal protein, the Sex Peptide (SP). Ectopic expression of SP in virgin females mimics the effect of mating on feeding behavior, demonstrating that SP is the main agent controlling this behavioral paradigm. Our observations identify enhanced feeding behavior as a novel component of the Drosophila PMR and suggest that SP represents a molecular link between energy acquisition and reproductive investment.