Is the low incidence of extrapyramidal side‐effects of antipsychotics associated with antimuscarinic properties?
Is the low incidence of extrapyramidal side‐effects of antipsychotics associated with antimuscarinic properties?
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抗精神病药锥体外系副作用发生率低是否与抗毒蕈碱特性有关？
DOI：
10.1111/j.2042-7158.1978.tb13177.x
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. Leysen
中科院分区：
文献类型：
--
作者：
Pierre M. Laduron;J. Leysen
阿扑吗啡的N-丙基同系物在改善人类帕金森综合征症状方面似乎比阿扑吗啡更有效（Cotzias，Papavasiliou等人，1976）。同样地，在黑质纹状体系统单侧损伤的小鼠（Ginos，Cotzias & others，1975; Pearl，Schumann & Wood，1976）和大鼠（Neumeyer，Dafeldecker & others，1977）中，N-丙基同系物在产生姿势不对称方面比阿扑吗啡更有效。现在已经评估了几种阿扑吗啡同系物在尾状核单侧病变小鼠中的多巴胺能效力，并将结果与其他使用不同多巴胺能活性指标的人的结果进行了比较。雄性Swiss-Webster小鼠（Taconic Farms，NY），在损伤时为2和23 g，在测试时为36-45 g，根据Lotti（1971）通过抽吸使尾状核单侧损伤。将药物溶于水中，口服、腹腔内和皮下给药均为0.01 ml gl。在给药前即刻和给药后15、30、60、120和240 min进行观察，最长持续时间为2 min。没有一只小鼠表现出姿势性
The N-propyl homologue of apomorphine appeared to be more potent than apomorphine in improving symptoms of parkinsonism in man (Cotzias, Papavasiliou & others, 1976). Likewise, the N-propyl homologue was more potent than apomorphine in producing postural asymmetries in mice (Ginos, Cotzias & others, 1975; Pearl, Schumann & Wood, 1976) and rats (Neumeyer, Dafeldecker & others, 1977) with unilateral lesions of the nigrostriatal system. The dopaminergic potency of several apomorphine homologues in mice with unilateral lesions of the caudate nucleus has now been assessed and the results compared with those of others who used different indicants of dopaminergic activity. Male Swiss-Webster mice (Taconic Farms, NY), 2&23 g at the time of lesioning and 36-45 g at testing, had unilateral lesions of the caudate nucleus made by suction according to Lotti (1971). Drugs were dissolved in water, and oral, intraperitoneal and subcutaneous medications were 0.01 ml gl. Observations, 2 min maximum duration, took place immediately before and 15, 30, 60, 120 and 240 min after medication. None of the mice exhibited postural