Antiphospholipid antibodies and stroke.
Antiphospholipid antibodies and stroke.
复制标题
抗磷脂抗体和中风。
DOI：
10.1007/s11886-004-0011-1
复制
发表时间：
2004
影响因子：
3.7
通讯作者：
Tuhrim,Stanley
中科院分区：
文献类型：
--
作者：
Tuhrim,Stanley
抗磷脂抗体与静脉和动脉血栓闭塞事件相关，包括中风。它们是抗体的异质家族，与带负电荷的膜结合磷脂或磷脂蛋白复合物反应。尽管在过去十年中取得了很大进展，但它们促进血栓形成的确切机制仍然未知。他们的存在增加了初次中风的风险，但可能不会复发。抗血栓方案一直是治疗的主要手段，但理想的治疗方法仍有待确定。本文回顾了历史，定义，协会和治疗这个复杂的实体。
Antiphospholipid antibodies are associated with venous and arterial thrombo-occlusive events, including stroke. They are a heterogeneous family of antibodies that react to negatively charged membrane-bound phospholipids or phospholipidprotein complexes. Despite much progress in the past decade, the precise mechanisms by which they promote thrombosis remain unknown. Increased risk of initial, but perhaps not recurrent, stroke has been associated with their presence. Antithrombotic regimens have been the mainstay of treatment, but the ideal therapeutic approach remains to be defined. This paper reviews the history, definition, associations, and treatment of this complex entity.