Defense reactions of mosquitoes to filarial worms: potential mechanism for avoidance of the response by Brugia pahangi microfilariae.
Defense reactions of mosquitoes to filarial worms: potential mechanism for avoidance of the response by Brugia pahangi microfilariae.
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蚊子对丝虫的防御反应：避免彭亨布鲁氏丝虫反应的潜在机制。
DOI：
10.1016/0022-2011(85)90126-0
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发表时间：
1985
影响因子：
3.4
通讯作者：
Lasee,BA
中科院分区：
文献类型：
--
作者：
Lafond,MM;Christensen,BM;Lasee,BA
三纹伊蚊、黑眼利物浦（LVP）和洛克菲勒（RKF）株对已侵入LVP、RKF或A.在接种后1、3和5天（PI）对离体三带绦虫中肠进行了评估。LVP和RKF中肠来源的mff几乎完全避免了黑化反应，并在LVP菌株A中正常发育。A. aegypti，并且尽管在RKF蚊子中超过90%的这些mff在感染后5天死亡，但是这些mff中的大多数没有黑化。埃及伊蚊肠源性mff也能够避免A. trivittatusin 33-43%的病例。穿透A.然而，Trivittatusmidguts并不显著影响MFF避免任何所检测蚊子中黑化反应的能力。接受检查的所有三种蚊子都接受同种异体和异种组织植入。所提供的数据支持这样的假设，即mff通过在迁移到血腔的过程中穿透中肠期间用中肠材料覆盖自身来避免相容性蚊子的免疫识别。
The melanization response ofAedes trivittatusand the black-eyed Liverpool (LVP) and Rocke-feller (RKF) strains ofAedes aegyptiagainst intrathoracically inoculatedBrugia pahangimicrofilariae (mff) that previously had penetrated LVP, RKF, orA. trivittatusmidguts in vitro was assessed at 1, 3, and 5 days postinoculation (PI). LVP and RKF midgut-derived mff almost totally avoided the melanization response and developed normally in LVP strainA. aegypti, and although over 90% of these mff died by 5 days PI in RKF mosquitoes, the majority of these were not melanized.A. aegyptimidgut-derived mff also were able to avoid the response ofA. trivittatusin 33–43% of the cases. Penetration throughA. trivittatusmidguts, however, did not significantly affect the ability of mff to avoid the melanization response in any of the mosquitoes examined. Allogeneic and xenogeneic tissue inplants were accepted by all three mosquito species examined. Data presented support the hypothesis that mff avoid immune recognition in compatible mosquitoes by coating themselves with midgut material(s) during penetration of the midgut in their migration to the hemocoel.