Clinical and Microbiologic Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers
Clinical and Microbiologic Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers
复制标题
DOI：
10.1902/jop.2013.130278
复制
发表时间：
2014-04-01
影响因子：
4.3
通讯作者：
Feres, Magda
中科院分区：
文献类型：
--
作者：
Faveri, Marcelo;Rebello, Allisson;Feres, Magda
背景资料：本研究的目的是评价甲硝唑（MTZ）和阿莫西林（AMX）在治疗吸烟者和非吸烟者的泛发性慢性牙周炎（CP）中的临床和微生物学效果。方法：选择吸烟者32例，非吸烟者32例，采用洁治根面平整术（SRP）联合MTZ治疗（400 mg，每日三次）和AMX（500 mg，每日三次）治疗14天。在基线和SRP后3个月进行临床和微生物学检查。结果：治疗后3个月，两组患者的各项临床指标均较治疗前有显著改善（P < 0.05）。非吸烟者治疗后探测深度（PD）<5 mm的部位平均数量较低。较少的非吸烟者在治疗后3个月表现出至少9个这些部位。非吸烟者在基线和治疗后3个月之间的平均PD和临床附着的增加在最初的深（PD 7 mm）部位也表现出最大的降低（P < 0.01）。最有益的变化，在微生物配置文件中也观察到在非吸烟者组，这表明在3个月的最低比例的橙子复杂，以及显着增加的比例放线菌属后treatment.Conclusion：吸烟者与CP的好处比非吸烟者的治疗SRP，MTZ，AMX的组合。
Background: The aim of the present study is to evaluate the clinical and microbiologic effects of the adjunctive use of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of smokers and non-smokers with generalized chronic periodontitis (CP).Methods: Thirty-two smokers and 32 non-smokers were selected and received scaling and root planing (SRP) combined with MTZ (400 mg three times daily) and AMX (500 mg three times daily) for 14 days. Clinical and microbiologic examinations were performed at baseline and 3 months after SRP. Nine subgingival plaque samples per patient were analyzed using checkerboard DNA-DNA hybridization.Results: Both groups presented a significant improvement in all clinical parameters at 3 months after therapy (P < 0.05). Non-smokers showed lower mean number of sites with probing depth (PD) 5 mm after therapy. Fewer non-smokers exhibited at least nine of these sites at 3 months after treatment. Non-smokers also presented the greatest reductions in mean PD and gain in clinical attachment between baseline and 3 months after therapy at initially deep (PD 7 mm) sites (P < 0.01). The most beneficial changes in the microbial profile were also observed in the non-smoker group, which showed the lowest proportions of the orange complex at 3 months, as well as a significant increase in the proportions of Actinomyces species after treatment.Conclusion: Smokers with CP benefit less than nonsmokers from treatment by the combination of SRP, MTZ, and AMX.