Effect of natural killer cells on syngeneic bone marrow: in vitro and in vivo studies demonstrating graft failure due to NK cells in an identical twin treated by bone marrow transplantation.
Effect of natural killer cells on syngeneic bone marrow: in vitro and in vivo studies demonstrating graft failure due to NK cells in an identical twin treated by bone marrow transplantation.
复制标题
自然杀伤细胞对同基因骨髓的影响：体外和体内研究表明，经过骨髓移植治疗的同卵双胞胎中的 NK 细胞导致移植失败。
作者：
G. Goss;M. Wittwer;W. Bezwoda;J. Herman;A. Rabson;L. Seymour;D. Derman;B. Mendelow
本文报告1例重症特发性再生障碍性贫血患者的骨髓移植，供者为同卵双生兄弟。尽管使用了同基因骨髓，但有两次植入失败。体外研究表明，来自受者的自然杀伤（NK）细胞显著抑制供体骨髓粒系祖细胞的生长。在第三次尝试中，在高剂量环磷酰胺（先前已显示对NK细胞具有抑制作用）后实现了成功的骨髓植入。我们的结论是NK细胞活性可能在骨髓衰竭中发挥重要作用，以及负责至少在某些情况下再生障碍性贫血。
Bone marrow transplantation for severe idiopathic aplastic anemia was undertaken in a patient, using his monozygotic twin brother as the donor. In spite of the use of syngeneic bone marrow, failure of engraftment occurred on two occasions. In vitro studies demonstrated that natural killer (NK) cells from the recipient markedly inhibited the growth of donor bone marrow granulocyte progenitor cells. On a third attempt, successful bone marrow engraftment was achieved following high-dose cyclophosphamide, which has previously been shown to be inhibitory to NK cells. We conclude that NK cell activity may play an important role in bone marrow failure as well as being responsible for at least some cases of aplastic anemia.
自然杀伤细胞在体外抑制人红细胞干细胞增殖。
影响因子：
20.3
作者：
Mangan,KF;Hartnett,ME;Matis,SA;Winkelstein,A;Abo,T
通讯作者：
Abo,T
自体同种异体人类 NK 细胞抑制体外粒细胞生成。
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hansson,M;Beran,M;Andersson,B;Kiessling,R
通讯作者：
Kiessling,R