Visual and auditory spatial and nonspatial delayed-response performance by Korsakoff and non-Korsakoff alcoholic and aging individuals.
Visual and auditory spatial and nonspatial delayed-response performance by Korsakoff and non-Korsakoff alcoholic and aging individuals.
复制标题
科尔萨科夫和非科尔萨科夫酗酒者和老年人的视觉和听觉空间和非空间延迟反应表现。
DOI：
10.1037//0735-7044.106.4.613
复制
发表时间：
1992
影响因子：
1.9
通讯作者：
Bonner,RT
中科院分区：
文献类型：
--
作者：
Oscar-Berman,M;Hutner,N;Bonner,RT
36名男性酗酒者(13名患有科萨科夫综合症)和24名对照组进行了对非人类灵长类前额叶皮质损伤敏感的视觉和听觉延迟反应任务。与其他受试者相比，Korsakoff患者一直处于受损状态。当要求视觉处理时间(短暂刺激持续时间)时，Korsakoff患者的损伤是明显的，随着对短期记忆需求的增加，缺陷变得更加夸张。在最困难的实验条件下，与27-49岁的年轻组相比，50岁以上的对照组和非Korsakoff酗酒者的表现略差。与科萨科夫的缺陷相比，与年龄相关的缺陷是温和的，随着任务要求的降低，年龄组差异消失。这一结果表明酒精中毒和正常的时间衰老与皮质病理有关，并表明前额叶损害伴随着酒精中毒性Korsakoff综合征。
Thirty-six male alcoholics (13 with Korsakoff's syndrome) and 24 controls performed visual and auditory delayed-response tasks sensitive to prefrontal cortical damage in nonhuman primates. Korsakoff patients were consistently impaired compared with other subjects. Impairments by Korsakoff patients were evident when demands were placed on visual processing time (brief stimulus durations), and the deficits became exaggerated with increased demands on short-term memory. Under the most difficult experimental conditions, controls and non-Korsakoff alcoholics who were over 50 years old performed somewhat worse compared with younger groups 27–49 years old. Age-linked deficits were mild compared with Korsakoffs' deficits, and age–group differences disappeared with easier task demands. The results implicate cortical pathology in alcoholism and normal chronological aging and suggest that prefrontal damage accompanies alcoholic Korsakoff's syndrome.