FATTY ACID COMPOSITION OF HUMAN DEPOT FAT
FATTY ACID COMPOSITION OF HUMAN DEPOT FAT
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DOI：
10.1042/bj0780541
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发表时间：
1961-01-01
影响因子：
4.1
通讯作者：
CROSSLEY, A
中科院分区：
文献类型：
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作者：
KINGSBURY, K;PAUL, S;CROSSLEY, A
通过气液色谱法和碱性异构化法研究了12名正常和动脉粥样硬化受试者的储存脂肪的脂肪酸组成。脂肪样本的采集部位对其脂肪酸模式几乎没有影响。人体贮库脂肪含有42-51%的油酸，21-30%的棕榈酸，5-8.5%的棕榈油酸和硬脂酸，5-8%的“亚油酸”和低于3%的具有两个以上双键的酸。大量的奇数和支链脂肪酸，C18和C10饱和酸和三不饱和酸（三烯），五烯和六烯出现在人类贮库脂肪。通过碱性异构化和碘值测定，贮库脂肪的脂肪酸组成与血浆和乳汁的甘油酯组成相似;它还显示出与这些部位的磷脂的一些相似性，但与胆固醇酯或总血浆脂肪酸不相似。在正常和动脉粥样硬化受试者的贮藏脂肪组成之间没有发现显著差异，除了可能增加三不饱和酸的浓度，特别是在动脉粥样硬化样品中与二烯和四烯有关的三不饱和酸的浓度。
The fatty acid composition of the depot fat from 12 subjects, both normal and atheromatous, was studied by gas-liquid chromatography and alkaline isomerization. The site from which the fat sample was taken had very little effect on its fatty acid pattern. Human depot fat was found to contain 42-51% of oleic acid, 21-30% of palmitic acid, 5-8.5% of pal-mitoleic acid and stearic acid, 5-8% of "linoleic" acid and under 3% of acids with more than 2 double bonds. Significant amounts of odd-numbered and branched-chain fatty acids, C18 and C10 saturated acids and of tri-unsaturated acids (trienes), pentaenes and hexaenes occur in human depot fat. The fatty acid composition of the depot fat is similar to that of the glycerides of plasma and milk as determined by alkaline isomerization and iodine values; it also shows some similarities with that of the phospholipids of these sites but not with the cholesteryl esters or total plasma fatty acids. No significant differences were found between the depot-fat composition of normal and atheromatous subjects, excepting possibly an increased concentration of tri-unsaturated acids, particularly in relation to the dienes and tetraenes, in the atheromatous samples.