Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines.
Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines.
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DOI：
10.3390/tropicalmed2030028
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发表时间：
2017-07-12
影响因子：
2.9
通讯作者：
Gallega CT
中科院分区：
文献类型：
--
作者：
Juayang AC;Lim JPT;Bonifacio AFV;Lambot AVL;Millan SM;Sevilla VZJN;Sy JKT;Villanueva PJ;Grajales CP;Gallega CT
5年来，从不同的临床标本中分离到646株铜绿假单胞菌，并测定其对常用抗铜绿假单胞菌抗生素的耐药性。感染来源以呼吸道(60.99%)和尿路(23.22%)为主，其次为漏出液和渗出液(2.01%)。样本来源以老年人居多(77.55%)，住院人数最多(67.03%)。阿米卡星的耐药率为7.5%，其次为哌拉西林/他唑巴坦(8.5%)和庆大霉素(13.5%)。26.7%的菌株对左氧氟沙星耐药。几乎100%的菌株对AmpC酶产生阳性，这可能表明对超广谱β-内酰胺酶具有诱导性耐药性。此外，在过去的三年里，人们注意到该地区的铜绿假单胞菌对氨曲南和庆大霉素的耐药性有所下降。此外，在五年中，平均MAR指数为0.17，这表明要么正确使用抗生素，要么大多数分离株不来自高危地区。铜绿假单胞菌的耐药率按标本来源比较无显著差异(p=0.662.0 5)，按年份段比较有显著差异(p=0.0 2)。
Over five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came from transudates and exudates (2.01%). Most of the samples were acquired from older adults (77.55%), most of whom were admitted (67.03%). Amikacin was found to be the most effective drug with a resistance rate of 7.5%, followed by piperacillin/tazobactam (8.5%) and gentamicin (13.5%). On the other hand, 26.7% of the isolates were resistant to levofloxacin. Almost 100% of the isolates were screened positive for AmpC production, which may suggest inducible resistance against expanded spectrum beta-lactamase. Furthermore, for the last three years, P. aeruginosa isolates from this area have been noted to have decreasing resistance only to aztreonam and gentamicin. Also, for five years, a mean MAR index of 0.17 was noted which indicates either proper antibiotic use or most isolates did not come from high-risk areas. Moreover, there was no significant difference in the resistance of P. aeruginosa when compared by specimen source (p = 0.662), but significant when compared by year band (p = 0.02).