Disuse osteoporosis: Physiological aspects
Disuse osteoporosis: Physiological aspects
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DOI：
10.1007/bf02406148
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发表时间：
2006
影响因子：
4.2
通讯作者：
G. D. Whedon
中科院分区：
文献类型：
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作者：
G. D. Whedon
石膏固定、卧床休息和失重状态都会导致钙流失，如果持续几个月，就会导致下肢明显脱矿。上肢是“不同”的骨骼（大概是基因编程不同），因为除了几个月的严重瘫痪之外，它们没有出现X射线可检测到的脱矿质。不活动时钙的大量损失伴随着氮的大量损失，这反映了肌肉萎缩。因此，我们不知道废用性骨质流失有多少是由于骨骼上的直接物理力减少造成的，有多少是由于骨膜上肌肉拉力的减少造成的，有多少可能是由于循环或其他变化造成的。
Immobilization in plaster, bed rest, and the weightless state all result in calcium loss which if continued for a few months will result in detectable demineralization of the lower extremities. The upper extremities are “different” bones (presumably differently programed genetically), for they have not been seen to develop X-ray-detectable demineralization except after several months of severe paralysis. The substantial losses of calcium in inactivity are accompanied by sizeable losses of nitrogren, reflective of muscle atrophy. Hence, we do not know how much of the bone loss in disuse is mediated by diminished direct physical forces on bone, how much by decreased muscle pull on periosteum, and how much perhaps by circulatory or other changes.