Sleep and synaptic homeostasis: a hypothesis
Sleep and synaptic homeostasis: a hypothesis
复制标题
DOI：
10.1016/j.brainresbull.2003.09.004
复制
发表时间：
2003-12-15
影响因子：
3.8
通讯作者：
Cirelli, C
中科院分区：
文献类型：
--
作者：
Tononi, G;Cirelli, C
在睡眠的大部分时间里，大脑皮层会受到慢波的影响，在脑电图中显示为 0.5 至 4.5 Hz 之间的振荡。慢波根据之前的清醒程度进行调节，在睡眠开始时达到最大，然后逐渐恢复到基线水平。本文讨论了关于慢波活动及其稳态调节的重要性的假设。假设如下： 1．觉醒与多个皮质回路中的突触增强有关；2．突触增强与慢波活动的稳态调节有关；3．慢波活动与突触缩小有关；4．突触缩小与睡眠对表现的有益影响有关。睡眠与突触稳态之间的假设联系得到了多项证据的支持，并导致了可测试的预测。 (C) 2003 Elsevier B.V. 保留所有权利。
During much of sleep, the cerebral cortex is rippled by slow waves, which appear in the electroencephalogram as oscillations between 0.5 and 4.5 Hz. Slow waves are regulated as a function of previous wakefulness, being maximal at the beginning of sleep and then progressively returning to a baseline level. This paper discusses a hypothesis about the significance of slow-wave activity and its homeostatic regulation. The hypothesis is as follows:1. Wakefulness is associated with synaptic potentiation in several cortical circuits;2. Synaptic potentiation is tied to the homeostatic regulation of slow-wave activity;3. Slow-wave activity is associated with synaptic downscaling;4. Synaptic downscaling is tied to the beneficial effects of sleep on performance.The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions. (C) 2003 Elsevier B.V. All rights reserved.