Lack of agreement between office and ambulatory blood pressure responses to hydrochlorothiazide
Lack of agreement between office and ambulatory blood pressure responses to hydrochlorothiazide
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DOI：
10.1016/j.amjhyper.2004.10.021
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发表时间：
2005-03-01
影响因子：
3.2
通讯作者：
Turner, ST
中科院分区：
文献类型：
--
作者：
Finkielman, JD;Schwartz, GL;Turner, ST
背景资料：通过诊室血压（OBP）和动态血压监测（ABPM）技术测量的抗高血压药物治疗反应之间的差异已被注意到，但很少进行分析。我们研究了是否OBP和24小时ABPM反应氢氯噻嗪不同，如果是这样，这些differences.Methods的相关性：OBP和ABPM反应氢氯噻嗪（25毫克/天，4周）测定228例原发性高血压，平均反应方法之间进行了比较，使用学生配对t检验。为了评估受试者之间OBP和ABPM反应之间一致性的差异，一致性的限度计算为OBP和ABPM反应之间的平均差+/-2标准差。
Background: Differences between the antihypertensive responses to drug therapy measured by office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) techniques have been noted but rarely analyzed. We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance of these differences.Methods: The OBP and ABPM responses to hydrochlorothiazide (25 mg/d, for 4 weeks) were measured in 228 subjects with essential hypertension, and mean responses were compared between methods using the Student paired t test. To assess variation in the agreement between OBP and ABPM responses among subjects, the limits of agreement were calculated as the mean difference between OBP and ABPM responses +/- 2 standard deviations.Results: The mean systolic OBP response was 4.8 mm Hg greater than the response measured by ABPM (-14.3 v -9.5 mm Hg, P