Functional Activation Patterns of Deep Brain Stimulation of the Anterior Nucleus of the Thalamus
Functional Activation Patterns of Deep Brain Stimulation of the Anterior Nucleus of the Thalamus
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DOI：
10.1016/j.wneu.2020.01.108
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发表时间：
2020-04-01
影响因子：
2
通讯作者：
Grewal, Sanjeet S.
中科院分区：
文献类型：
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作者：
Middlebrooks, Erik H.;Lin, Chen;Grewal, Sanjeet S.
背景：丘脑（ANT）的脑深部电刺激（DBS）是最近批准用于耐药性癫痫患者的治疗方法。nuc.eus到目前为止，对作用机制的理解还很差，缺乏体内生物标志物。我们提出了一种方法，用于调查在体内的刺激效果，使用血氧水平依赖性（BOLD）磁共振成像（MRI），并提出了与ANT DBS.METHODS相关的脑激活模式：两名患者接受ANT DBS癫痫进行BOLD MRI使用块设计后，DBS编程为交替开/关在30秒的块。使用表面电生理记录触发扫描仪，以检测DBS周期。共获得9次运行，并使用一般线性模型进行分析。结果：主动ANT刺激在大脑的几个区域内产生激活，包括丘脑，双侧前扣带和后扣带皮层，楔前叶，内侧前额叶皮层，杏仁核，腹侧被盖区，海马，纹状体和右角回。使用块设计BOLD MRI，我们能够显示ANT DBS引起的广泛激活。默认模式和边缘网络的多个区域重叠，表明这些节点可能调节ANT DBS控制癫痫发作的效果。
BACKGROUND: Deep brain stimulation (DBS) of the nuc.eus of the thalamus (ANT) is a recently approved therapy for patients with drug-resistant epilepsy. To date, there is a poor understanding of the mechanism of action and lack of in vivo biomarkers. We propose a method for investigating the in vivo stimulation effects using blood-oxygen-level-dependent (BOLD) magnetic resonance imaging (MRI) and present the brain activation pattern associated with ANT DBS.METHODS: Two patients undergoing ANT DBS for epilepsy underwent BOLD MRI using a block design after the DBS was programmed to alternate ON/OFF in 30-second blocks. The scanner was triggered using surface electrophysiologic recordings to detect the DBS cycle. Nine total runs were obtained and were analyzed using a general linear model.RESULTS: Active ANT stimulation produced activation within several areas of the brain, including the thalamus, bilateral anterior cingulate and posterior cingulate cortex, precuneus, medial prefrontal cortex, amygdala, ventral tegmental area, hippocampus, striatum, and right angular gyrus.CONCLUSIONS: Using block-design BOLD MRI, we were able to show widespread activation resulting from ANT DBS. Overlap with multiple areas of both the default mode and limbic networks was shown, suggesting that these nodes may modulate the effect of seizure control with ANT DBS.