RELATIONSHIPS OF GENERALIZED AND REGIONAL ADIPOSITY TO INSULIN SENSITIVITY IN MEN
RELATIONSHIPS OF GENERALIZED AND REGIONAL ADIPOSITY TO INSULIN SENSITIVITY IN MEN
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DOI：
10.1172/jci118083
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发表时间：
1995-07-01
影响因子：
15.9
通讯作者：
GRUNDY, SM
中科院分区：
文献类型：
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作者：
ABATE, N;GARG, A;GRUNDY, SM
区域性和全身性肥胖对胰岛素敏感性的相对影响尚未完全确定。因此，我们研究了胰岛素敏感性（使用高胰岛素、正糖钳技术和[3-H-3]葡萄糖转换测量）与全身肥胖（通过氢密度测定）和局部肥胖的关系。后者通过测定腹部皮下、腹膜内和腹膜后脂肪团（使用磁共振成像）以及躯干和周围皮褶厚度的总和来评估，研究了39名不同类型肥胖的健康中年男性。总的来说，腹膜内和腹膜后脂肪仅占全身脂肪的11%和7%。葡萄糖处置率（R(d)）和剩余肝葡萄糖输出（rHGO）值在40亩/米(2)。最小胰岛素输注量与总脂肪（r = -0.61和0.50）、皮下脂肪（r = -0.62和0.50）、躯干皮褶厚度之和（r = -0.72和0.57）和腹腔内脂肪（r = -0.51和0.44）相关，但与腹膜后脂肪无关。在调整体脂总量后，R(d)和rHGO值与躯干皮褶厚度总和的相关性最高（部分R分别= -0.40和0.33）。我们得出结论，皮下脂肪在男性肥胖相关的胰岛素抵抗中起主要作用，而腹膜内脂肪和腹膜后脂肪的作用较小。
The relative impacts of regional and generalized adiposity on insulin sensitivity have not been fully defined. Therefore, we investigated the relationship of insulin sensitivity (measured using hyperinsulinemic, euglycemic clamp technique with [3-H-3]glucose turnover) to total body adiposity(determined by hydrodensitometry) and regional adiposity. The latter was assessed by determining subcutaneous abdominal, intraperitoneal, and retroperitoneal fat masses (using magnetic resonance imaging) and the sum of truncal and peripheral skinfold thicknesses, 39 healthy middle-aged men with a wide range of adiposity were studied. Overall, the intraperitoneal and retroperitoneal fat constituted only 11 and 7% of the total body fat. Glucose disposal rate (R(d)) and residual hepatic glucose output (rHGO) values during the 40 mu/m(2) . min insulin infusion correlated significantly with total body fat (r = -0.61 and 0.50, respectively), subcutaneous abdominal fat (r = -0.62 and 0.50, respectively), sum of truncal skinfold thickness (r = -0.72 and 0.57, respectively), and intraperitoneal fat (r = -0.51 and 0.44, respectively) but not to retroperitoneal fat. After adjusting for total body fat, the R(d) and rHGO values showed the highest correlation with the sum of truncal skinfold thickness (partial r = -0.40 and 0.33, respectively). We conclude that subcutaneous truncal fat plays a major role in obesity-related insulin resistance in men, whereas intraperitoneal fat and retroperitoneal fat have a lesser role.