NEURAL PATHOGENESIS OF EXPERIMENTAL SCRAPIE AFTER INTRAOCULAR INOCULATION OF HAMSTERS
NEURAL PATHOGENESIS OF EXPERIMENTAL SCRAPIE AFTER INTRAOCULAR INOCULATION OF HAMSTERS
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DOI：
10.1016/0014-4886(83)90271-6
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发表时间：
1983-01-01
影响因子：
5.3
通讯作者：
MARSH, RF
中科院分区：
文献类型：
--
作者：
BUYUKMIHCI, N;GOEHRINGHARMON, F;MARSH, RF
仓鼠玻璃体内接种瘙痒病剂。所有动物都出现痒病和典型的痒病视网膜变性。接种的眼睛的视网膜变性比未接种的眼睛更严重。痒病剂在接种的眼睛中复制很快。然后感染性沿着同侧视神经缓慢传播到大脑。大脑中的复制与未接种疫苗的眼睛视网膜中的复制平行。结果支持痒病的神经传播。
Hamsters were inoculated intravitreally with the scrapie agent. All animals developed scrapie and retinal degeneration typical of scrapie. The retinal degeneration was greater in the inoculated eyes than in the uninoculated eyes. Replication of the scrapie agent was rapid in the inoculated eye. Infectivity then spread slowly down the ipsilateral optic nerve to the brain. The replication in the brain pralleled that in the retina of the uninoculated eye. The results support a neural spread of scrapie.