Role of apoptotic cell death in sepsis
Role of apoptotic cell death in sepsis
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DOI：
10.1080/00365540310015692
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发表时间：
2003-09-01
影响因子：
--
通讯作者：
Karl, IE
中科院分区：
文献类型：
--
作者：
Hotchkiss, RS;Tinsley, KW;Karl, IE
脓毒症是许多重症监护室重症患者发病和死亡的主要原因。脓毒症患者器官衰竭和死亡的病理生理学仍然难以捉摸。这篇综述重点介绍了我们对脓毒症细胞死亡机制、死亡细胞类型以及对免疫的影响的最新进展。广泛的细胞凋亡导致免疫细胞耗竭，并可能损害患者根除原发感染的能力，并容易发生继发性院内感染。脓毒症患者的外周循环淋巴细胞凋亡也增加，并且与疾病的严重程度相关。此外，最近的证据表明，凋亡细胞的摄取会损害存活细胞的免疫功能并导致免疫抑制。对脓毒症的这种新认识可能会带来新的治疗方法，包括阻止细胞凋亡的药物。
Sepsis is the leading cause of morbidity and mortality in critically ill patients in many intensive care units. The pathophysiology of organ failure and death in patients with sepsis remain elusive. This review focuses on recent advances in our understanding of the mechanisms of cell death in sepsis, the types of cells that are dying and the consequences on immunity. Extensive apoptotic death results in immune cell depletion and may compromise the ability of the patient to eradicate the primary infection and predispose to secondary nosocomial infections. Peripheral circulating lymphocyte apoptosis is also increased in patients with sepsis and correlates with the severity of the disease. In addition, recent evidence indicates that uptake of apoptotic cells impairs the immune function of surviving cells and contributes to immunosuppression. This new understanding of sepsis may lead to novel therapeutic approaches including pharmacological agents that block apoptosis.