NEUROBEHAVIORAL MANIFESTATIONS IN OBSTRUCTIVE SLEEP-APNEA SYNDROME BEFORE AND AFTER TREATMENT WITH CONTINUOUS POSITIVE AIRWAY PRESSURE
NEUROBEHAVIORAL MANIFESTATIONS IN OBSTRUCTIVE SLEEP-APNEA SYNDROME BEFORE AND AFTER TREATMENT WITH CONTINUOUS POSITIVE AIRWAY PRESSURE
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DOI：
10.1093/sleep/15.suppl_6.s17
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发表时间：
1992-01-01
期刊：
影响因子：
5.6
通讯作者：
ROULEAU, I
中科院分区：
文献类型：
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作者：
MONTPLAISIR, J;BEDARD, MA;ROULEAU, I
阻塞性睡眠呼吸暂停综合征（OSAS）的特征是睡眠期间反复发生呼吸暂停，导致反复低氧血症发作和正常睡眠模式的持续中断。警觉性障碍和神经心理缺陷是这种情况下的主要症状。该领域的主要问题之一涉及夜间低氧血症、睡眠中断、白天过度嗜睡和认知缺陷之间的相互作用。这项研究的结果表明，警觉性障碍主要是由于夜间低氧血症。然而，在认知缺陷中，低氧血症似乎在执行和精神任务中起主要作用，而注意力和记忆功能似乎与警觉性障碍有关。治疗后，与低氧血症相关的缺陷和一定程度的嗜睡持续存在。这些结果提高了严重OSAS患者出现不可逆缺氧性中枢神经系统（CNS）损伤的可能性。
Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent apneas during sleep, resulting in repetitive hypoxemic episodes and a constant interruption of the normal sleep pattern. Vigilance impairment and neuropsychological deficits are among the main symptoms seen in this condition. One of the major questions in this field concerns the reciprocal interactions between nocturnal hypoxemia, sleep disruption, excessive daytime sleepiness and cognitive deficits. Results of this study suggest that vigilance impairment is attributable mostly to nocturnal hypoxemia. However, in cognitive deficits, hypoxemia seems to play a major role in executive and psychomotor tasks, whereas attention and memory functions appear to be related to vigilance impairment. After treatment, hypoxemia-related deficits and some degree of sleepiness persist. These results raise the possibility of an irreversible anoxic central nervous system (CNS) damage in severe OSAS.