Long‐term safety of isotretinoin as a treatment for acne vulgaris
Long‐term safety of isotretinoin as a treatment for acne vulgaris
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异维A酸治疗寻常痤疮的长期安全性
DOI：
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发表时间：
1994
影响因子：
10.3
通讯作者：
W. Cunliffe
中科院分区：
文献类型：
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作者：
V. Goulden;A. Layton;W. Cunliffe
我们评估了720例接受一个或多个疗程的异维甲酸治疗的患者可能的长期副作用，平均随访期为4.9年（范围2？12年）。大多数患者（442）接受了总累积剂量为120？200毫克/公斤体重。162例患者接受的累积剂量<120 mg/kg体重，116例患者接受的累积剂量<200 mg/kg。52例患者（7.2%）在随访期间报告了持续症状。未发现年龄、性别、累积剂量或异维甲酸疗程数与报告的可能副作用发生率之间存在相关性。报告的症状主要为肌肉骨骼（2%）或粘膜皮肤（4.8%），所有病例均为轻度。认为干皮病、干眼综合征、关节痛和可能的湿疹加重是罕见但可能的长期副作用。本研究的结果表明，异维A酸治疗痤疮是一种安全的药物，没有严重的长期副作用。
We assessed possible long‐term side‐effects of isotretinoin therapy in 720 patients who had received one or more courses of treatment, and had a mean follow‐up period of 4.9 years (range 2?12 years). Most patients (442) had received a total cumulative dose of 120?200 mg/kg body weight. One hundred and sixty‐two patients received a cumulative dose of <120 mg/kg body weight, and 116 received a cumulative dose <200 mg/kg. Fifty‐two patients (7.2%) reported persistent symptoms during the follow‐up period. No correlation was found between age, sex, cumulative dose, or number of courses of isotretinoin and occurrence of reported possible side‐effects. The reported symptoms were predominantly musculoskeletal (2%) or mucocutaneous (4.8%), and were mild in all cases. Xeroderma, dry eye syndrome, arthralgia, and possible exacerbation of eczema, were considered to be infrequent but probable long‐term side‐effects. The findings of this study indicate that isotretinoin in the treatment of acne is a safe drug, with no serious long‐term side‐effects.