Co-culture Model for Hepatitis B Virus Infection Using iPSC-Derived Liver Progenitor Cells and Liver Sinusoidal Endothelial Cells
Co-culture Model for Hepatitis B Virus Infection Using iPSC-Derived Liver Progenitor Cells and Liver Sinusoidal Endothelial Cells
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使用 iPSC 来源的肝祖细胞和肝窦内皮细胞的乙型肝炎病毒感染共培养模型
DOI：
10.1007/978-1-0716-2557-6_7
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发表时间：
2022
影响因子：
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通讯作者：
Taketomo Kido
中科院分区：
文献类型：
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作者：
Misao HIMENO;Shin-Wei Chen;Taketomo Kido
为了了解乙型肝炎病毒（HBV）复杂的生命周期，有必要开发一种不同肝细胞的HBV感染共培养系统。我们已经开发出从人诱导多能细胞（iPSCs）中产生肝祖细胞（LPCs）、肝细胞和肝窦内皮细胞（LSECs）的培养系统。利用这些细胞，我们建立了一个共培养系统来研究HBV的感染和体外复制。
In order to understand the complicated life cycle of hepatitis B virus (HBV), it is necessary to develop a co-culture system for HBV infection using various liver cells. We have already developed culture systems to generate liver progenitor cells (LPCs), hepatocytes, and liver sinusoidal endothelial cells (LSECs) from human induced pluripotent cells (iPSCs). Using those cells, we established a co-culture system to study HBV infection and replication in vitro.