Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers
Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers
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DOI：
10.1021/ja056726i
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发表时间：
2006-02-01
影响因子：
15
通讯作者：
Rotello, VM
中科院分区：
文献类型：
--
作者：
Hong, R;Han, G;Rotello, VM
我们在这里展示了使用2 nm核心金纳米颗粒将染料有效载荷有效递送到细胞中，通过谷胱甘肽在颗粒表面上的位置交换释放。体外实验表明，在添加谷胱甘肽后，药物类似物有效释放。细胞培养实验显示纳米颗粒的快速摄取和有效载荷的有效释放。谷胱甘肽在释放过程中的作用通过在通过将谷胱甘肽乙酯引入细胞中实现谷胱甘肽水平的瞬时增加后改善有效负载释放来证明。
We demonstrate here the effective delivery of a dye payload into cells using 2-nm core gold nanoparticles, with release occurring via place exchange of glutathione onto the particle surface. In vitro experiments demonstrate effective release of drug analogues upon addition of glutathione. Cell culture experiments show rapid uptake of nanoparticle and effective release of payload. The role of glutathione in the release process was demonstrated through improved payload release upon transient increase in glutathione levels achieved via introduction of glutathione ethyl ester into the cell.