Cognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention?
Cognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention?
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DOI：
10.1016/0166-4328(95)00143-3
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发表时间：
1996-02
影响因子：
2.7
通讯作者：
M. Voytko
中科院分区：
文献类型：
--
作者：
M. Voytko
基底前脑胆碱能系统（BFCS）胆碱能神经元记忆功能障碍的胆碱能假说可能是导致老年性记忆障碍和阿尔茨海默病（AD）的重要原因。这一假说将焦点集中在AD实验动物模型中的BFCS上。与啮齿类动物中的大量研究相反，在BFCS病变猴中进行的研究较少。内侧隔核/Broca斜角带核（MS/NDBB）和Meynert基底核（NBM）可能参与猴不同的认知功能。虽然很少有研究专门针对猴子MS/NDBB的认知功能问题，但有一些迹象表明这些区域可能对记忆很重要。相比之下，病变的NBM不一贯破坏记忆功能的猴子。最近的电生理和病变的猴子的研究表明，NBM可能发挥更重要的作用，注意功能，损害是早期和显着的特征，AD患者。
The cholinergic hypothesis of memory dysfunctionof cholionergic neurons in the basal forebrain cholinergic system (BFCS) may be responsible for the memory deficits associated with aging and Alzheimer's disease (AD). This hypothesis directed focus on the BFCS in experimental animal models of AD. In contrast to numerous studies in rodents, fewer investigations have been conducted in monkeys with BFCS lesions. The medial septal nucleus/nucleus of the diagonal band of Broca (MS/NDBB) and the nucleus basalis of Meynert (NBM) may be involved in different cognitive functions in monkeys. Although few investigations have specifically addressed the issue of cognitive functions of the MS/NDBB in monkeys, there is some indication that these regions may be important for memory. In contrast, lesions of the NBM do not consistently disrupt mnemonic functions in monkeys. Recent electrophysiological and lesion studies of monkeys indicate that the NBM may play a more important role in attention functions, impairments of which are an early and significant feature of patients with AD.