A Forgotten Method to Induce Experimental Chronic Renal Failure in the Rat by Ligation of the Renal Parenchyma
A Forgotten Method to Induce Experimental Chronic Renal Failure in the Rat by Ligation of the Renal Parenchyma
复制标题
一种被遗忘的通过结扎肾实质诱导大鼠实验性慢性肾衰竭的方法
DOI：
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发表时间：
2006
影响因子：
--
通讯作者：
J. Valdivielso
中科院分区：
文献类型：
--
作者：
L. Pérez;S. Ros;A. Cardus;E. Fernández;J. Valdivielso
Background: Animal models of chronic renal failure have been widely used in the experimental nephrology laboratories. The most common technique used is the 5/6 reduction of renal mass, either by surgical resection or by infarction. Methods: In the present work, we describe a forgotten technique based in the ligation of the renal parenchyma in both renal poles. This technique combines the advantages of the resection model, like the reproducibility and homogeneity, with the ones of the infarction technique, like the absence of bleeding. Results: 8 weeks after the procedure, animals showed a decrease in creatinine clearance together with an increase in plasma creatinine. Furthermore, glomeruli of animals with 5/6 nephrectomy showed a marked hypertrophy, with a glomerular volume significantly higher than control animals. Serum levels of parathyroid hormone were also increased, consistent with the development of secondary hyperparathyroidism. Conclusions: We conclude that the present technique is a valid and improved tool for the study of chronic renal failure.
低钙血症对于慢性肾功能衰竭继发性甲状旁腺功能亢进症的发生可能不是必需的。
DOI：
10.1172/jci112666
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Lopez-Hilker,S;Galceran,T;Chan,YL;Rapp,N;Martin,KJ;Slatopolsky,E
通讯作者：
Slatopolsky,E
影响因子：
6.1
作者：
Goek, Oemer-Necmi;Prehn, Cornelia;Meisinger, Christa
通讯作者：
Meisinger, Christa