Pattern Formation on Discrete Gel Matrix Based on DNA Computing
Pattern Formation on Discrete Gel Matrix Based on DNA Computing
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DOI：
10.1007/s00354-018-0047-1
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发表时间：
2019-01-01
影响因子：
2.6
通讯作者：
Murata, Satoshi
中科院分区：
文献类型：
--
作者：
Hosoya, Takuto;Kawamata, Ibuki;Murata, Satoshi
在这篇文章中，我们考虑用DNA计算实现一个元胞自动机。该系统是建立在模拟生物组织细胞隔间的结构化水凝胶基质上的反应-扩散系统。由于细胞自动机是由水凝胶基质实现的，所以该系统被称为细胞自动机，理论上它能够通过化学反应形成图案并进行计算。重点介绍了细胞自动机实现的技术方面，如细胞阵列的制作、细胞间分子通讯的实现、细胞状态转换的实现等。在对每个技术要素进行评价的同时，还描述了一些简单的图案形成实验演示。
In this paper, we consider the implementation of a cellular automaton by DNA computing. The proposed system is a reaction-diffusion system built on a structured hydrogel matrix that mimics cellular compartments of biological tissues. Since the cellular automaton is materialized by a hydrogel matrix, the system is called gellular automaton which is theoretically capable of pattern formation and computation by chemical reactions. We focus on technical aspects of the implementation of the gellular automata, such as fabrication of the array of cells, the realization of inter-cellular molecular communication, and how to realize state transitions of cells. Along with the evaluation of each technical element, some simple experimental demonstrations of pattern formation are described.