MRI study of regional variations of pharyngeal wall compliance in cats.
MRI study of regional variations of pharyngeal wall compliance in cats.
复制标题
猫咽壁顺应性区域差异的 MRI 研究。
DOI：
10.1152/jappl.1998.85.5.1884
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Pack,AI
中科院分区：
文献类型：
--
作者：
Brennick,MJ;Ogilvie,MD;Margulies,SS;Hiller,L;Gefter,WB;Pack,AI
Upper airway compliance indicates the potential of the airway to collapse and is relevant to the pathogenesis of obstructive sleep apnea. We hypothesized that compliance would vary over the rostral-to-caudal extent of the pharyngeal airway. In a paralyzed isolated upper airway preparation in cats, we controlled static upper airway pressure during magnetic resonance imaging (MRI, 0.391-mm resolution). We measured cross-sectional area and anteroposterior and lateral dimensions from three-dimensional reconstructed MRIs in axial slices orthogonal to the airway centerline. High-retropalatal (HRP), midretropalatal (MRP), and hypopharyngeal (HYP) regions were defined. Regional compliance was significantly increased from rostral to caudal regions as follows: HRP < MRP < HYP (P< 0.0001), and compliance differences among regions were directly related to collapsibility. Thus our findings in the isolated upper airway of the cat support the hypothesis that regional differences in pharyngeal compliance exist and suggest that baseline regional variations in compliance and collapsibility may be an important factor in the pathogenesis and treatment of obstructive sleep apnea.
