Impaired path integration in mice with disrupted grid cell firing
Impaired path integration in mice with disrupted grid cell firing
复制标题
网格细胞放电紊乱的小鼠路径整合能力受损
DOI：
10.1038/s41593-017-0039-3
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发表时间：
2018-01-01
影响因子：
25
通讯作者：
Monyer, Hannah
中科院分区：
文献类型：
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作者：
Gil, Mariana;Ancau, Mihai;Monyer, Hannah
路径集成(PI)是一种高度保守、基于自运动的导航策略。自从在内侧内嗅皮层发现网格细胞以来，神经生理学数据和计算模型表明这些神经元为PI服务。然而，由于缺乏对网格细胞活动的选择性操纵和适当的行为评估，支持这一假说的更直接的经验证据一直缺乏。在这里，我们报告说，通过从海马区移除NMDA谷氨酸受体，可以选择性地破坏小鼠的网格细胞活动，而网格细胞的激活被破坏是PI表现受损的原因。值得注意的是，基因操作没有影响内侧内嗅觉皮质和海马体中其他空间选择性细胞的活动。通过直接将网格细胞的活动与PI联系起来，这些结果有助于更好地理解网格细胞如何支持导航和空间记忆。
Path integration (PI) is a highly conserved, self-motion-based navigation strategy. Since the discovery of grid cells in the medial entorhinal cortex, neurophysiological data and computational models have suggested that these neurons serve PI. However, more direct empirical evidence supporting this hypothesis has been missing due to a lack of selective manipulations of grid cell activity and suitable behavioral assessments. Here we report that selective disruption of grid cell activity in mice can be achieved by removing NMDA glutamate receptors from the retro-hippocampal region and that disrupted grid cell firing accounts for impaired PI performance. Notably, the genetic manipulation did not affect the activity of other spatially selective cells in the medial entorhinal cortex and the hippocampus. By directly linking grid cell activity to PI, these results contribute to a better understanding of how grid cells support navigation and spatial memory.