Effects of nomifensine and its metabolites on dihydropteridine reductase.
Effects of nomifensine and its metabolites on dihydropteridine reductase.
复制标题
诺米芬辛及其代谢物对二氢蝶啶还原酶的影响。
DOI：
10.1111/j.2042-7158.1984.tb04412.x
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Abell,CW
中科院分区：
文献类型：
--
作者：
Shen,RS;Sheng,WL;Abell,CW
Nomifensine and three of its metabolites were studied as potential inhibitors of dihydropteridine reductase. Purified enzyme preparations from human liver and the P2fraction of rat striatal synaptosomes were used as enzyme sources. Nomifensine and its 3−hydroxyl derivative inhibit this enzyme from both sources at 1·3 to 3·5 times 10−4m (150 values). 4−Hydroxylated nomifensines, however, non‐competitively inhibited this enzyme with Kivalues of 2·8 to 4·4 times 10−5m. Dihydropteridine reductase regenerates tetrahydrobiopterin, the required cofactor for the hydroxylation of tyrosine and tryptophan, from quinonoid dihydrobiopterin. Inhibition of this enzyme could reduce the availability of the biopterin cofactor for the synthesis of dopamine and 5−hydroxytryptamine.
