Erythropoietin and its receptor in breast cancer: Correlation with steroid receptors and outcome
Erythropoietin and its receptor in breast cancer: Correlation with steroid receptors and outcome
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DOI：
10.1158/1055-9965.epi-06-1023
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发表时间：
2007-10-01
影响因子：
3.8
通讯作者：
Castanas, Elias
中科院分区：
文献类型：
--
作者：
Pelekanou, Vassiliki;Kampa, Marilena;Castanas, Elias
自分泌/旁分泌促红细胞生成素（EPO）的作用，促进细胞存活和介导的各种实体瘤，包括乳腺癌，这个系统的预后和治疗利益的问题。EPO/EPOR的表达在某些组织中是类固醇依赖性的;然而，EPO/EPOR和类固醇受体在乳腺癌中的明确关系迄今尚未建立。最近，类固醇受体的领域已经扩大，包括由膜相关受体介导的快速效应，调节细胞存活或凋亡。本研究的目的是评估乳腺癌中EPO/EPOR和膜相关类固醇受体表达的预后意义，并与其他已建立的标志物[雌激素受体（ER）-孕激素受体（PR）状态和Her 2表达]和61例乳腺癌标本中的缺氧诱导因子1核定位进行比较。
Autocrine/paracrine erythropoietin (EPO) action, promoting cell survival and mediated by its receptor (EPOR) in various solid tumors, including breast carcinoma, questions about the prognostic and therapeutic interest of this system. The expression of EPO/EPOR is steroid dependent in some tissues; however, a clear relationship of EPO/EPOR and steroid receptors in breast cancer has not been established thus far. Recently, the field of steroid receptors has expanded, including rapid effects mediated by membrane-associated receptors, regulating cell survival or apoptosis. The aim of this study was to evaluate EPO/EPOR and membrane-associated steroid receptor expression in breast carcinoma, in view of their prognostic significance, compared with other established markers [estrogen receptor (ER)-progesterone receptor (PR) status and Her2 expression] and hypoxia-induced factor 1 nuclear localization in 61 breast cancer specimens followed for