The Role of Circadian Rhythms in Fatal Arrhythmias and the Potential Impact of Intervention for Sleep-Disordered Breathing
The Role of Circadian Rhythms in Fatal Arrhythmias and the Potential Impact of Intervention for Sleep-Disordered Breathing
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DOI：
10.2174/1381612821666150706104857
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Fukuda, Keiichi
中科院分区：
文献类型：
--
作者：
Aizawa, Yoshiyasu;Kohno, Takashi;Fukuda, Keiichi
心源性猝死的发生存在一定的昼夜节律。视交叉上核是哺乳动物体内的“主时钟”。此外，在基础研究中已经成功地分离出了几个昼夜节律基因，并且大量的关键因素形成了人类的昼夜节律。危重事件的发生存在明显的昼夜节律模式，但这些特征因疾病而异。在这篇综述中，我们总结了目前对死亡事件的基本机制及其与特定心血管疾病的关联的理解，这些疾病显示出致命事件的昼夜发作。我们还总结了最近对睡眠障碍呼吸的深刻理解。睡眠呼吸障碍与心血管疾病之间的密切关系可能为我们提供了一种新的预防心源性猝死的干预措施。
There exist circadian patterns in the occurrence of sudden cardiac death. The suprachiasmatic nuclei is the 'master clock' in mammalian bodies. Furthermore, several circadian genes have been successfully isolated in basic studies and a huge variety of key players form the human circadian rhythm. Obvious circadian patterns are present in the occurrence of critical events, but those characteristics differ greatly according to each disease. In this review we summarized the current understanding of the basic mechanism and association with specific cardiovascular diseases that demonstrate a circadian onset of fatal events. We also summarized the recent deep understanding of sleep-disordered breathing. The close relationship between sleep-disordered breathing and cardiovascular diseases may provide us with the possibility of a novel intervention against sudden cardiac death.