Preface: Forum on Advances in Biocidal Materials and Interfaces
Preface: Forum on Advances in Biocidal Materials and Interfaces
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前言：杀菌材料和界面进展论坛
DOI：
10.1021/acsami.0c06495
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发表时间：
2020
影响因子：
9.5
通讯作者：
Schanze, Kirk S.
中科院分区：
文献类型：
--
作者：
Palermo, Edmund F.;Schanze, Kirk S.
本期ACS Applied Materials & Interfaces包含一个论坛，主题是材料和界面领域的最新进展，这些材料和界面对各种病原微生物发挥作用，包括广谱细菌，真菌甚至病毒。据世界卫生组织称，抗菌素耐药性的迅速上升，加上每年批准的新抗菌药物数量急剧下降，已经引发了一场极为紧迫的公共卫生危机。1在我们发布本论坛之际，当前的COVID 19全球公共卫生危机凸显了对接触包膜病毒材料的迫切需求。尽管大多数关于生物杀灭材料的论文倾向于关注抗生素耐药细菌（有充分的理由），但预计在不久的将来，对SARS-CoV 2等包膜病毒的重新关注将迅速增加。许多关于抗菌材料和界面的文献已经研究了膜破裂的机制。这将是有趣的，在未来发现这种知识可能（或可能不）转移到包膜病毒中的脂质双层的破坏程度。在Klibanov的早期工作中发现了这种概念的一些先例。[2]尽管目前尚不清楚，但应用这些技术或类似技术防止SARS-CoV 2传播的前景显然是一个高度优先事项。此外，重症COVID 19患者发生的肺部继发性细菌感染（肺炎）也凸显了杀菌涂层在医院环境中的至关重要性。在这个论坛上，您将发现各种各样的新想法、方法和发展在活性材料领域，可以用于对材料和感兴趣的表面进行自我消毒。Mitra等人的综述检查了各种铜基抗菌涂层在临床环境中的高效性，并与银基方法进行了对比。Lara及其同事证明了银纳米颗粒在预防临床相关硅橡胶弹性体材料上真菌生物膜方面的效用。Ghosh等人介绍了他们在新型抗菌和抗病毒涂层方面的工作，这些涂层具有共价连接的季铵基团。Volmer和合著者报告了亚微米粗糙度对细菌粘附的影响。Krumm和同事们强调了他们在抗菌聚紫罗烯上的努力，这种抗菌聚紫罗烯在接触时杀死细菌。Zhang及其同事展示了一种新的抗菌微凝胶方法，该方法含有与磁性纳米颗粒结合的儿茶酚。Song及其同事提供了设计抗菌表面的材料选择和策略的观点。
This issue of ACS Applied Materials & Interfaces contains a forum on the topic of recent advances in the field of materials and interfaces that exert activity against a variety of pathogenic microorganisms, including a broad spectrum of bacteria, fungi, and even viruses. According to the World Health Organization, the rapid rise in antimicrobial resistance, which is further compounded by the recalcitrant decline in the number of new antimicrobial drugs approved each year, has given rise to a critically urgent public health crisis. 1 As we publish this forum, the current worldwide public health crisis of COVID19 has highlighted the particularly emergent need for materials that inactivate enveloped viruses on contact. Although the majority of papers on biocidal materials tend to focus on antibiotic drug-resistant bacteria (for good reason), renewed focus on enveloped viruses such as SARS-CoV2 is expected to increase rapidly in the near future. Much of the literature on antibacterial materials and interfaces has examined a mechanism of membrane disruption. It will be interesting in the future to discover the extent to which such knowledge may (or may not) be transferrable to the disruption of the lipid bilayer in enveloped viruses. Some precedent for such a concept is found in the early work of Klibanov. 2 Although it remains unknown at present, the prospect of applying these technologies, or similar, against the spread of SARS-CoV2 is clearly a high priority. In addition, the secondary bacterial infections of the lungs (pneumonia) that occur in critically ill COVID19 patients also highlight the paramount importance of biocidal coatings in the hospital setting.In this forum, you will find a wide variety of new ideas, methods, and developments in the area of active materials that can serve to self-disinfect materials and surfaces of interest. A review by Mitra et al. examines the high efficacy of various copper-based antimicrobial coatings in the clinical setting, drawing contrast with silver-based approaches. Lara and coworkers demonstrate the utility of silver nanoparticles in preventing fungal biofilms on clinically relevant silicone elastomer materials. Ghosh et al. present their work on novel antibacterial and antiviral coatings that feature covalently linked quaternary ammonium groups. Volmer and co-authors report the effects of sub-micrometer roughness on bacterial adhesion. Krumm and co-workers highlight their efforts on antibacterial polyionenes that kill bacteria on contact. Zhang and co-workers showed a new approach to antibacterial microgels that contain catechols in conjuction with magnetic nanoparticles. Song and co-workers provide a perspective on choice of materials and strategies for designing antimicrobial surfaces.