The role of circulating lipoprotein lipase and adiponectin on the particle size of remnant lipoproteins in patients with diabetes mellitus and metabolic syndrome
The role of circulating lipoprotein lipase and adiponectin on the particle size of remnant lipoproteins in patients with diabetes mellitus and metabolic syndrome
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DOI：
10.1016/j.cca.2014.10.029
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发表时间：
2015-02-02
影响因子：
5
通讯作者：
Murakami, Masami
中科院分区：
文献类型：
--
作者：
Shirakawa, Takashi;Nakajima, Katsuyuki;Murakami, Masami
背景：2型糖尿病（T2DM）和代谢综合征（MetS）患者残馀脂蛋白（RLPs）颗粒大小的调节因素尚未得到很好的阐明。方法：对T2DM、MetS和有脂肪肝和无脂肪肝的健康对照者进行研究。测定空腹肝素前血浆中残余脂蛋白(RLP)-胆固醇（RLP- c）、脂酰甘油三酯（RLP- tg）、小密度低密度脂蛋白胆固醇（sdLDL-C）、脂蛋白脂肪酶（LPL）、肝甘油三酯脂肪酶（HTGL）和脂联素浓度。通过RLP-TG/RLP-C比值估算RIP粒度。结果：T2DM和MetS患者血清TG、RLP-C、RLP-TG、RLP-TG/RLP-C比值和sdLDL-C均显著高于对照组。脂肪肝和高血清TG与RLP-TG/RLP- c比值增加显著相关，RLP-TG/RLP- c比值用于估计对照组、T2DM和MetS的RLP粒度。肝素前血浆LPL和脂联素与正常、T2DM和MetS患者的RLP-TG/RLP-C比值呈负相关。LPL也与脂联素呈正相关。结论：T2DM和MetS患者RLP颗粒大小明显大于对照组，并受循环LPL和脂联素调节，而HTGL不受调节。脂肪肝和高TG与RLP大颗粒的发生率显著相关。(C) 2014年Elsevier B.V.出版
Background: The factors regulating particle size of remnant lipoproteins (RLPs) in type 2 diabetes (T2DM) and metabolic syndrome (MetS) cases have not been well elucidated.Methods: T2DM, MetS and healthy controls with and without a fatty liver were studied. Remnant lipoprotein (RLP)-cholesterol (RLP-C) and RIP-triglyceride (RLP-TG), small dense LDL-cholesterol (sdLDL-C), lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and adiponectin concentrations were measured in the fasting pre-heparin plasma. The RIP particle size was estimated by the RLP-TG/RLP-C ratio.Results: The serum TG, RLP-C, RLP-TG, RLP-TG/RLP-C ratio and sdLDL-C were significantly greater in T2DM and MetS than in controls. Fatty liver and high serum TG were significantly associated with an increased RLP-TG/RLP-C ratio which was used to estimate the particle size of RLP in controls, T2DM and MetS. LPL and adiponectin in the pre-heparin plasma were inversely correlated with RLP-TG/RLP-C ratio in normal, T2DM and MetS. LPL was also positively correlated with adiponectin in all three cases.Conclusions: RLP particle size in T2DM and MetS was significantly larger than in controls and was regulated by circulating LPL and adiponectin, but not HTGL. Fatty liver and high TG were significantly associated with the prevalence of the large RLP particle size. (C) 2014 Published by Elsevier B.V.