Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis.
Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis.
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DOI：
10.1006/smim.1996.0055
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发表时间：
1997-02
影响因子：
7.8
通讯作者：
A. Chinnaiyan;Vishva M. Dixit
中科院分区：
文献类型：
--
作者：
A. Chinnaiyan;Vishva M. Dixit
Fas/APO-1是TNF受体家族的成员，在免疫系统中起主导作用，下调免疫应答并促进T细胞介导的细胞毒性。天然配体或激动剂抗体激活Fas/APO-1可启动细胞凋亡。然而，直到最近，Fas/APO-1参与细胞死亡机制的机制一直是一个谜。在这里，我们描述了一个拟议的分子机制，这种细胞表面死亡受体信号自杀反应。
Fas/APO-1 is a member of the TNF receptor family and plays a dominant role in the immune system, down-regulating the immune response and contributing to T-cell-mediated cytotoxicity. Activation of Fas/APO-1 by either natural ligand or agonist antibody initiates apoptosis. Until recently, however, the mechanism by which Fas/APO-1 engages the cell death machinery has been an enigma. Here we describe a proposed molecular mechanism by which this cell surface death receptor signals the suicide response.