Drosophila as a tool for personalized medicine: a primer.
Drosophila as a tool for personalized medicine: a primer.
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果蝇作为个性化医学的工具：底漆。
DOI：
10.2217/pme.10.65
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发表时间：
2010-11
影响因子：
2.3
通讯作者：
Cagan R
中科院分区：
文献类型：
--
作者：
Kasai Y;Cagan R
个性化医疗的目标是用最好的药物治疗每个患者：最佳的治疗效果和最小的副作用。基因组革命正在迅速确定遗传对疾病状态的贡献以及其对药物疗效和毒性的贡献。进行全基因组研究的能力已经导致了大量的候选基因和/或其相关变体;然而，了解哪些具有治疗重要性正在成为个性化医疗领域最大的未满足需求。一个相关的问题是，需要改进我们的方法来识别和表征治疗药物的背景下，复杂的基因组景观的完整的身体。果蝇已被证明是理解人类发育基本生物机制的有力工具。本文将综述果蝇作为基因和药物发现的整体动物工具。我们将研究如何使用果蝇来分类来自人类全基因组扫描的无数命中，并显着改善药物开发的早期步骤。
The goal of personalized medicine is to treat each patient with the best drug: optimal therapeutic benefit with minimal side effects. The genomic revolution is rapidly identifying the genetic contribution to the diseased state as well as its contribution to drug efficacy and toxicity. The ability to perform genome-wide studies has led to an overwhelming number of candidate genes and/or their associated variants; however, understanding which are of therapeutic importance is becoming the greatest unmet need in the personalized medicine field. A related issue is the need to improve our methods of identifying and characterizing therapeutic drugs in the context of the complex genomic landscape of the intact body. Drosophila have proven to be a powerful tool for understanding the basic biological mechanisms of human development. This article will review Drosophila as a whole animal tool for gene and drug discovery. We will examine how Drosophila can be used to both sort through the myriad of hits coming from human genome-wide scans and to dramatically improve the early steps in pharmaceutical drug development.