A preliminary report of increased plasma levels of IL-33 in bipolar disorder: Further evidence of pro-inflammatory status
A preliminary report of increased plasma levels of IL-33 in bipolar disorder: Further evidence of pro-inflammatory status
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DOI：
10.1016/j.jad.2013.12.042
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发表时间：
2014-03-20
影响因子：
6.6
通讯作者：
Teixeira, Antonio Lucio
中科院分区：
文献类型：
--
作者：
Barbosa, Izabela Guimaraes;Morato, Isabela Boechat;Teixeira, Antonio Lucio
背景：最近的研究结果表明炎症在双相情感障碍（BD）的神经生物学中起重要作用。白细胞介素33 （Interleukin 33, IL-33）是一种具有多种功能的细胞因子，可能是调节转录的核因子和“警报因子”。IL-33通过受体ST2发挥部分功能，该受体也以可溶性形式存在（sST2）。本研究旨在评估BD患者IL-33和sST2的血浆水平。方法：采用酶联免疫吸附试验（ELISA）检测46例BD患者（心境愉悦者23例，躁狂者23例）和23例健康对照者血浆中il - 33和sST2水平。BD患者为年龄和性别匹配的健康对照。结果：IL-33水平在BD患者中较高（p=0.02），而sST2无差异（p=0.55）。血浆il - 33和sST2水平与年龄无关，也不受临床合并症和正在使用的药物的影响。结论：这些发现证实了双相障碍是一种具有促炎特征的多系统疾病。(C) 2014 Elsevier B.V.版权所有
Background: Recent findings suggest an important role for inflammation in the neurobiology of bipolar disorder (BD). Interleukin 33 (IL-33) is a cytokine with multiple functions and may act as a nuclear factor regulating transcription and as an "alarmin". IL-33 exerts part of its function through the receptor ST2 that also exists in a soluble form (sST2). This study was performed to evaluate IL-33 and sST2 plasma levels in BD patients.Methods: We evaluated IL33 and sST2 plasma levels of 46 BD patients (23 in euthymia and 23 in mania) and 23 healthy controls using enzyme-linked immunosorbent assay (ELISA). BD patients were age and gender matched healthy controls.Results: IL-33 levels were higher in BD patients (p=0.02) but there was no difference in sST2 (p=0.55). IL33 and sST2 plasma levels were not correlated with age, neither was influenced by clinical comorbidities nor medications in use.Conclusion: These findings corroborate the view of BD as a multisystem condition with a proinflammatory profile. (C) 2014 Elsevier B.V. All rights reserved.