Clay content and pH: soil characteristic associations with the persistent presence of chronic wasting disease in northern Illinois
Clay content and pH: soil characteristic associations with the persistent presence of chronic wasting disease in northern Illinois
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DOI：
10.1038/s41598-017-18321-x
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发表时间：
2017-12-22
影响因子：
4.6
通讯作者：
Mateus-Pinilla, Nohra E.
中科院分区：
文献类型：
--
作者：
Dorak, Sheena J.;Green, Michelle L.;Mateus-Pinilla, Nohra E.
环境水库是重要的传染病的传播和持久性，但实证分析相对较少。自然环境是朊病毒的储存库，朊病毒可引起慢性消耗性疾病（CWD），并影响传染给易感鹿的风险。土壤是一种环境成分，被证明影响朊病毒的传染性和持久性。在这里，我们提供了第一个景观预测模型CWD完全基于土壤特性。我们建立了一个提升回归树模型预测的可能性，持久存在的CWD在北方伊利诺伊州的一个地区，使用CWD监测鹿和土壤数据。我们评估了可能的途径，土壤特性可能会增加CWD通过环境污染传播的可能性的结果。土壤粘粒含量和pH值是CWD持续存在的最重要的预测土壤特性。结果表明，在粘土百分比小于18%且土壤pH值大于6.6的环境中，朊病毒的暴露更大。这些特征可能会改变固定在土壤中的朊病毒的可用性，并有助于参与慢性消耗病感染的流行病学复杂性在自然种群的白色尾鹿的环境风险因素。
Environmental reservoirs are important to infectious disease transmission and persistence, but empirical analyses are relatively few. The natural environment is a reservoir for prions that cause chronic wasting disease (CWD) and influences the risk of transmission to susceptible cervids. Soil is one environmental component demonstrated to affect prion infectivity and persistence. Here we provide the first landscape predictive model for CWD based solely on soil characteristics. We built a boosted regression tree model to predict the probability of the persistent presence of CWD in a region of northern Illinois using CWD surveillance in deer and soils data. We evaluated the outcome for possible pathways by which soil characteristics may increase the probability of CWD transmission via environmental contamination. Soil clay content and pH were the most important predictive soil characteristics of the persistent presence of CWD. The results suggest that exposure to prions in the environment is greater where percent clay is less than 18% and soil pH is greater than 6.6. These characteristics could alter availability of prions immobilized in soil and contribute to the environmental risk factors involved in the epidemiological complexity of CWD infection in natural populations of white tailed deer.