WHO recommendations for misoprostol use for obstetric and gynecologic indications
WHO recommendations for misoprostol use for obstetric and gynecologic indications
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DOI：
10.1016/j.ijgo.2012.12.009
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发表时间：
2013-05-01
影响因子：
3.8
通讯作者：
de Souza, Joao Paulo
中科院分区：
文献类型：
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作者：
Tang, Jennifer;Kapp, Nathalie;de Souza, Joao Paulo
背景：米索前列醇，一种前列腺素E-1类似物，刺激子宫收缩和宫颈成熟。一些随机试验和系统评价已经评估了它在妇产科疾病中的应用。米索前列醇价格便宜，在室温下稳定，在80多个国家都有售，这使得它在资源匮乏的环境中特别有用。世卫组织认识到米索前列醇在生殖健康中的关键作用，并将其使用建议纳入4项生殖健康指南，重点是引产、预防和治疗产后出血以及自然流产和人工流产的管理。方法和结果：所有指南均按照WHO指南制定手册编写。该过程包括：确定优先问题和关键成果;检索证据;评估和综合证据;拟订建议;以及规划传播、执行、影响评价和更新。本报告总结了根据每项指南使用米索前列醇的建议。结论：本综合参考文件旨在使临床医生和决策者能够快速获得并比较在各种生殖健康环境中使用米索前列醇的建议。(C)2013年国际妇产科联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Background: Misoprostol, a prostaglandin E-1 analog, stimulates uterine contractility and cervical ripening. A number of randomized trials and systematic reviews have evaluated its use in obstetric and gynecologic conditions. Misoprostol-is inexpensive, stable at room temperature, and available in more than 80 countries, making it particularly useful in resource-poor settings. WHO recognizes the crucial role of misoprostol in reproductive health and has incorporated recommendations for its use into 4 reproductive health guidelines focused on induction of labor, prevention and treatment of postpartum hemorrhage, and management of spontaneous and induced abortion. Methods and results: All guidelines were prepared in accordance with the WHO Handbook for Guideline Development. The process included: identification of priority questions and critical outcomes; retrieval of evidence; assessment and synthesis of evidence; formulation of recommendations; and planning for dissemination, implementation, impact evaluation, and updating. The present report summarizes recommendations for misoprostol use in line with each guideline. Conclusion: The present comprehensive reference document was designed to enable clinicians and policy makers to quickly access and compare recommendations for the use of misoprostol in various reproductive health settings. (C) 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.