AN IMMUNODOMINANT ANTIGEN OF BRUGIA-MALAYI IS AN ASPARAGINYL-TRANSFER-RNA SYNTHETASE
AN IMMUNODOMINANT ANTIGEN OF BRUGIA-MALAYI IS AN ASPARAGINYL-TRANSFER-RNA SYNTHETASE
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DOI：
10.1016/0014-5793(95)01092-s
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发表时间：
1995-10-23
期刊：
影响因子：
3.5
通讯作者：
LEBERMAN, R
中科院分区：
文献类型：
--
作者：
KRON, M;MARQUARD, K;LEBERMAN, R
淋巴丝虫病是由马来丝虫（Brugia malayi）、帝汶丝虫（Brugia timori）、班氏吴策线虫（Wuchereria bancrofti）和盘尾丝虫（Onchocerca volvulus）感染引起的，它们共同感染全世界约2亿人。一个主要的线虫抗原的蛋白质序列同源性分析表明，它是一个II类氨酰-tRNA合成酶。生产过剩，纯化和验证主要是B。马来抗原是天冬酰胺酰-tRNA合成酶。
Lymphatic filariasis is caused by infection with the filarial nematodes Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca volvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode antigen suggested that it was a class II aminoacyl-tRNA synthetase. The overproduction, purification and verification that the major B. malayi antigen is an asparaginyl-tRNA synthetase is described.