Left atrial dilatation resulting from chronic mitral regurgitation decreases spatiotemporal organization of atrial fibrillation in left atrium.
Left atrial dilatation resulting from chronic mitral regurgitation decreases spatiotemporal organization of atrial fibrillation in left atrium.
复制标题
慢性二尖瓣反流引起的左心房扩张会降低左心房心房颤动的时空组织。
DOI：
10.1152/ajpheart.01032.2003
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Olgin,JeffreyE
中科院分区：
文献类型：
--
作者：
Everett4th,ThomasH;Verheule,Sander;Wilson,EmilyE;Foreman,Scott;Olgin,JeffreyE
已证明，快速心房起搏 (RAP)、慢性二尖瓣反流 (MR) 和对照动物心房颤动 (AF) 模型的心房传导特性存在差异。我们假设这些传导差异将随着房颤的发生而持续，这将影响房颤的时空组织，从而导致房颤的模型特定特征。通过对从高密度光学测绘获得的电描记图进行频域分析，将患有 RAP 和 MR 的动物的右心房 (RA) 和左心房 (LA) 的 AF 与对照动物进行比较。随访时，切除心脏并进行灌注，并使用 16 × 16 光电二极管阵列记录 RA 和 LA 游离壁各 2 × 2 cm 区域的光学动作电位。通过额外刺激诱导 AF，记录每只狗的几次 2.4 秒 AF 发作，并计算快速傅里叶变换。确定主频率（DF），并计算组织（组织指数，OI）作为主峰及其谐波下的面积与光谱总面积的比率。每个事件的所有可能的电描记图对都是互相关的。与对照或 RAP 模型中的 AF 相比，慢性 MR 模型中的 LA AF 显示最高 DF、DF 域数量和频率梯度有所增加。此外，MR 模型 LA 中的 OI 和相关系数也有所下降。这些结果表明 MR 模型中的 AF 底物可能与对照或 RAP 模型中的不同。
Atrial conduction properties have been shown to differ among animal atrial fibrillation (AF) models of rapid atrial pacing (RAP), chronic mitral regurgitation (MR), and control. We hypothesized that these conduction differences would continue with the onset of AF, which would affect AF spatiotemporal organization, resulting in model-specific characteristics of AF. With frequency domain analysis of electrograms acquired from high-density optical mapping, AF from the right (RA) and left (LA) atrium in animals with RAP and MR were compared with control animals. At follow-up, the hearts were excised and perfused, and optical action potentials were recorded from a 2 × 2-cm area each of the RA and LA free wall with a 16 × 16 photodiode array. AF was induced with extra stimuli, several 2.4-s AF episodes were recorded in each dog, and a fast Fourier transform was calculated. The dominant frequency (DF) was determined, and the organization (organization index, OI) was calculated as the ratio of the area under the dominant peak and its harmonics to the total area of the spectrum. All possible pairs of electrograms for each episode were cross-correlated. LA AF in the chronic MR model showed an increase in the highest DF, the number of DF domains, and in frequency gradient compared with AF in control or RAP models. In addition, there was a decrease in OI and in the correlation coefficients in the LA of the MR model. These results suggest that the AF substrate in the MR model may be different from that of control or RAP models.