Novel chlorine‐extending polymer coating with prolonged antiviral activity against SARS‐CoV ‐2
Novel chlorine‐extending polymer coating with prolonged antiviral activity against SARS‐CoV ‐2
复制标题
新型氯-延长聚合物涂层，具有针对 SARS-CoV 的长效抗病毒活性 -2
DOI：
10.1111/lam.13804
复制
发表时间：
2022
影响因子：
2.4
通讯作者：
Qiao, M.
中科院分区：
文献类型：
--
作者：
Zhang, Y.;Choi, Y. W.;Demir, B.;Ekbataniamiri, F.;Fulton, M. L.;Ma, M.;Schang, L. M.;Purevdorj‐Gage, L.;Qiao, M.
我们之前报道了一种新型聚合物表面涂层，即HaloFilm™，它可以固定并延长表面上氯的抗菌活性。在这项研究中，我们证明了HaloFilm在不锈钢和棉纱布上应用时的持续抗病毒效果，这两种模型分别是无孔和多孔表面，用于对抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。HaloFilm应用和氯化后48小时以及病毒挑战后2小时，无孔和多孔表面上的接种物滴度分别降低2.25 ± 0.33和≥4.36 ± 0.23 log 10 TCID 50。在HaloFilm涂层表面上，病毒的半衰期（13.86分钟）比在铜上报告的半衰期（46.44分钟）短。
We previously reported a novel polymeric surface coating, namely, HaloFilm™ that can immobilize and extend the antimicrobial activity of chlorine on surfaces. In this study, we demonstrated the continuous antiviral efficacy of HaloFilm when applied on stainless steel and cotton gauze as two representative models for non‐porous and porous surfaces against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Forty‐eight hours post HaloFilm application and chlorination and 2 h post the viral challenge, the inoculum titre was reduced by 2.25 ± 0.33 and ≥4.36 ± 0.23 log10TCID50on non‐porous and porous surfaces, respectively. The half‐life of the virus was shorter (13.86 min) on a HaloFilm‐coated surface than what has been reported on copper (46.44 min).