Translocation t(3;22)(q23;q11) in three patients with diffuse large B cell lymphoma.
Translocation t(3;22)(q23;q11) in three patients with diffuse large B cell lymphoma.
复制标题
三名弥漫性大 B 细胞淋巴瘤患者的易位 t(3;22)(q23;q11)。
作者：
D. Leroux;M. Stul;J. Sotto;C. Bastard;P. Couderc;J. Bensa;M. Monteil;J. Cassiman;P. Jalbert
在我们的134例诊断为非霍奇金淋巴瘤（NHL）和克隆性染色体异常的患者中，发现3例显示相同的t（3;22）（q28;q11）易位。所有患者均为老年人，均为孤立性淋巴结肿大和弥漫性大无裂细胞淋巴瘤。所有患者均表达B细胞免疫表型，并且在接受积极化疗后均进入完全缓解期。因此，这种易位可以描述弥漫性大细胞NHL的特定亚型。
In our series of 134 patients with a diagnosis of non-Hodgkin's lymphoma (NHL) and clonal chromosomal abnormalities, three were found to show an identical t(3;22)(q28;q11) translocation. All were old patients with isolated lymphadenomegaly and diffuse large noncleaved cell lymphoma. All expressed a B cell immunophenotype, and all entered a complete remission when treated with aggressive chemotherapy. This translocation could, therefore, delineate a particular subtype of diffuse large cell NHL.