ADRENAL CORTICAL ACTIVITY IN DEPRESSIVE ILLNESS
ADRENAL CORTICAL ACTIVITY IN DEPRESSIVE ILLNESS
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DOI：
10.1176/ajp.128.1.31
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发表时间：
1971-01-01
影响因子：
17.7
通讯作者：
BUNNEY, WE
中科院分区：
文献类型：
--
作者：
CARPENTER, WT;BUNNEY, WE
作者研究了肾上腺皮质活动的中枢控制的四个方面和外周代谢的三个方面。他们的研究结果表明，在抑郁症期间，中枢控制机制功能正常，但皮质醇活动的外周测量显示出有趣的异常。在抑郁症期间，生产率和代谢清除率均升高，但维持正常的24小时平均血浆皮质醇浓度。恢复后，生产率下降，而代谢清除率仍然很高，导致血浆皮质醇浓度低。作者还讨论了放射性同位素稀释法调查皮质醇动力学的影响。
The authors investigated four aspects of central control of adrenal cortical activity and three aspects of peripheral metabolism. Their results suggest that the central control mechanisms function normally during depression, but the peripheral measures of cortisol activity revealed interesting abnormalities. During depression, both the production rate and the metabolic clearance rate were elevated, but a normal 24-hour mean plasma cortisol concentration was maintained. On recovery, the production rate fell while the metabolic clearance rate remained high, resulting in a low plasma cortisol concentration. The authors also discuss the implications of investigating cortisol dynamics with radio-isotope dilution methods.