CARDIOPROTECTIVE EFFECTS OF A C1 ESTERASE INHIBITOR IN MYOCARDIAL-ISCHEMIA AND REPERFUSION
CARDIOPROTECTIVE EFFECTS OF A C1 ESTERASE INHIBITOR IN MYOCARDIAL-ISCHEMIA AND REPERFUSION
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DOI：
10.1161/01.cir.91.2.393
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发表时间：
1995-01-15
期刊：
影响因子：
37.8
通讯作者：
LEFER, AM
中科院分区：
文献类型：
--
作者：
BUERKE, M;MUROHARA, T;LEFER, AM
研究背景心肌缺血再灌注损伤主要是由多形核白细胞（PMN）引起的。补体系统起着重要的作用，作为一种趋化剂，影响粘附分子的表达和中性粒细胞accumulation.Methods和结果在本研究中，C1酯酶抑制剂（C1 INH）的心脏保护作用进行了研究，在猫模型的心肌缺血和再灌注（90分钟的缺血，然后再灌注270分钟）。再灌注前10分钟给予C1 INH（15 mg/kg）与赋形剂相比显著减轻心肌坏死（坏死面积分别为10+/-2%和29+/-2%; P
Background Myocardial injury after ischemia and reperfusion can be attributed largely to the effects of polymorphonuclear leukocytes (PMN). The complement system plays an important role as a chemotactic agent, affecting adhesion molecule expression and neutrophil accumulation.Methods and Results In the present study, the cardioprotective effects of C1 esterase inhibitor (C1 INH) were examined in a feline model of myocardial ischemia and reperfusion (90 minutes of ischemia followed by 270 minutes of reperfusion). C1 INH (15 mg/kg) administered 10 minutes before reperfusion significantly attenuated myocardial necrosis compared with vehicle (10+/-2% and 29+/-2% necrosis as a proportion of area at risk, respectively; P