The associations between multisensory temporal processing and symptoms of schizophrenia.
The associations between multisensory temporal processing and symptoms of schizophrenia.
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DOI：
10.1016/j.schres.2016.09.035
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发表时间：
2017-01
影响因子：
4.5
通讯作者：
Wallace MT
中科院分区：
文献类型：
--
作者：
Stevenson RA;Park S;Cochran C;McIntosh LG;Noel JP;Barense MD;Ferber S;Wallace MT
最近对精神分裂症的神经生物学解释包括强调感觉处理的变化。这些感觉和知觉缺陷可对更高层次的认知过程和临床症状产生级联效应。在精神分裂症中一直观察到的感觉功能障碍的一种形式是时间处理的改变。在这项研究中，我们调查了精神分裂症患者（SCZ）和年龄匹配的健康对照者的听觉和视觉模式内部和之间的时间加工。SCZ患者表现为听觉和视觉颞叶加工异常，以及多感觉颞叶加工功能障碍，这种功能障碍超出了单感觉加工功能障碍。最重要的是，这些多感觉时间缺陷与幻觉的严重程度有关。非典型多感觉时间知觉与临床症状之间的这种联系表明，精神分裂症的临床症状可能至少部分是（多）感觉障碍的级联效应的结果。这些结果在潜在的神经基础和可能的影响补救方面进行了讨论。
Recent neurobiological accounts of schizophrenia have included an emphasis on changes in sensory processing. These sensory and perceptual deficits can have a cascading effect onto higher-level cognitive processes and clinical symptoms. One form of sensory dysfunction that has been consistently observed in schizophrenia is altered temporal processing. In this study, we investigated temporal processing within and across the auditory and visual modalities in individuals with schizophrenia (SCZ) and age-matched healthy controls. Individuals with SCZ showed auditory and visual temporal processing abnormalities, as well as multisensory temporal processing dysfunction that extended beyond that attributable to unisensory processing dysfunction. Most importantly, these multisensory temporal deficits were associated with the severity of hallucinations. This link between atypical multisensory temporal perception and clinical symptomatology suggest that clinical symptoms of schizophrenia may be at least partly a result of cascading effects from (multi)sensory disturbances. These results are discussed in terms of underlying neural bases and the possible implications for remediation.