Triflic acid-mediated synthesis of thioglycosides
Triflic acid-mediated synthesis of thioglycosides
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DOI：
10.1039/c9ob01610d
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发表时间：
2019-09-28
影响因子：
3.2
通讯作者：
Demchenko, Alexei, V
中科院分区：
文献类型：
--
作者：
Escopy, Samira;Singh, Yashapat;Demchenko, Alexei, V
描述了一种在三氟酸存在下，由全乙酸酯合成硫代糖苷的有效方法。该方法具有反应速度快、产物产率高等特点。一些活性糖系列在亚化学计量比三氟甲基磺酸(TfOH)存在的情况下具有高效率，这与其他已知协议相反，这些协议需要多个当量的Lewis酸才能达到高转化率。
An efficient synthesis of thioglycosides from per-acetates in the presence of triflic acid is described. The developed protocol features high reaction rates and product yields. Some reactive sugar series give high efficiency in the presence of sub-stoichiometric trifluoromethanesulfonic acid (TfOH) in contrast to other known protocols that require multiple equivalents of Lewis acids to reach high conversion rates.